A STAT-1 knockout mouse model for Machupo virus pathogenesis
نویسندگان
چکیده
منابع مشابه
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متن کاملAssembly of a functional Machupo virus polymerase complex.
Segmented negative-sense viruses of the family Arenaviridae encode a large polymerase (L) protein that contains all of the enzymatic activities required for RNA synthesis. These activities include an RNA-dependent RNA polymerase (RdRP) and an RNA endonuclease that cleaves capped primers from cellular mRNAs to prime transcription. Using purified catalytically active Machupo virus L, we provide a...
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ژورنال
عنوان ژورنال: Virology Journal
سال: 2011
ISSN: 1743-422X
DOI: 10.1186/1743-422x-8-300